Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation Running title: Role of Ulk1 in clearance of organelles in RBCs
نویسندگان
چکیده
Mondira Kundu, Tullia Lindsten,, Chia-Ying Yang, Junmin Wu, Fangping Zhao, Ji Zhang, Mary A. Selak, Paul A. Ney, Craig B. Thompson. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104; Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN 38105; Department of Pediatrics, Children’s Hospital and University of Pennsylvania, Philadelphia, PA 190104; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104.
منابع مشابه
Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation.
Production of a red blood cell's hemoglobin depends on mitochondrial heme synthesis. However, mature red blood cells are devoid of mitochondria and rely on glycolysis for ATP production. The molecular basis for the selective elimination of mitochondria from mature red blood cells remains controversial. Recent evidence suggests that clearance of both mitochondria and ribosomes, which occurs in r...
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1Department of Pathology and Laboratory Medicine and 2Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia; 3Department of Biochemistry, St Jude Children’s Research Hospital, Memphis, TN; 4Department of Pediatrics, Children’s Hospital of Philadelphia, and University of Pennsylvania, Philadelphia; and 5Department of Cancer Biology, University of Pennsylvania, Phila...
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